Blog Post Title: Daily Stock Updates – August 4, 2023

Introduction: Welcome to today’s blog post, where we will be discussing the latest financial results and corporate updates from some of the stocks I own. In this post, we will focus on the second-quarter 2023 reports and recent business highlights of Ovid Therapeutics, Plains All American, KALA BIO, Achilles Therapeutics, and AC Immune. These updates provide valuable insights into the performance and future prospects of these companies, which can help us make informed decisions regarding our investment portfolios. Let’s delve into the details and explore the developments for today, August 4, 2023

Ovid Therapeutics Inc. Reports Major Milestones and Promising Developments in Q2 2023

Ovid Therapeutics Inc. (NASDAQ: OVID), a biopharmaceutical company specializing in treatments for rare epilepsies and seizure-related disorders, recently released its business updates and financial results for the second quarter of 2023. The company highlighted several key achievements, including the completion of the single ascending dose (SAD) portion of the Phase 1 trial evaluating OV329, a potential next-generation GABA-aminotransferase inhibitor.

In addition, Ovid Therapeutics announced an equity investment and collaboration with Graviton Bioscience to develop highly selective ROCK2 inhibitors, targeting rare neurological conditions. This strategic move enhances Ovid’s pipeline with potential first-in-class and best-in-class ROCK2 inhibitors, addressing the underlying causes of various neurological disorders.

The company’s expansion efforts also entail the appointment of a Chief Scientific Officer and a Chief Medical Officer, bolstering its scientific leadership team. With this experienced team at the helm, Ovid Therapeutics is dedicated to advancing compounds with unique mechanisms of action for seizure-related disorders.

Regarding regulatory filings, Takeda, in collaboration with Ovid Therapeutics, continues to anticipate submissions for soticlestat in Lennox-Gastaut syndrome and Dravet syndrome within its fiscal year 2024.

As an investor, these updates reflect positively on Ovid Therapeutics’ commitment to developing groundbreaking therapies that have the potential to transform the lives of individuals with rare epilepsies and seizure-related disorders. The addition of the ROCK2 inhibitor programs to their pipeline is particularly promising, as it may address the underlying causes of various neurological conditions.

Based on these recent developments and the potential impact they could have on Ovid’s future growth, it is recommended to maintain a position in the company’s stock. The accomplishments and advancements made in the second quarter demonstrate a strong trajectory for Ovid Therapeutics, making it an attractive investment opportunity in the biopharmaceutical industry.

Note: This blog post is for informational purposes only and should not be taken as financial advice. Always do thorough research and analysis before making any investment decisions.

Plains All American Pipeline, L.P. Reports Strong Q2 Results and Expansion Plans

Plains All American Pipeline, L.P. (Nasdaq: PAA) and Plains GP Holdings (Nasdaq: PAGP) have recently released their second-quarter results and provided updated guidance for 2023, showcasing their continued growth and expansion efforts.

Company Profile

Plains All American Pipeline, L.P. is a leading midstream energy company that owns and operates a vast network of pipelines, storage facilities, and terminals. They provide transportation and storage services for crude oil, natural gas liquids (NGLs), and natural gas.

Summary of Press Release

In the second quarter of 2023, Plains All American Pipeline, L.P. delivered impressive financial results. Net income attributable to PAA reached $293 million, while net cash provided by operating activities stood at $888 million. Adjusted EBITDA attributable to PAA was reported at $597 million, reflecting the company’s strong performance.

Moreover, Plains announced a bolt-on acquisition in the Permian Basin, further expanding its portfolio. A subsidiary of Plains Oryx Permian Basin LLC acquired Diamondback Energy’s 43% interest in OMOG JV LLC for approximately $225 million, solidifying their presence in this strategic region.

Additionally, the company provided updates regarding its NGL segment. They sanctioned the Plains Fort Saskatchewan (PFS) Train 1 debottlenecking project, increasing its capacity by approximately 30 Mb/d. They also highlighted connectivity projects to both the Co-Ed Pipeline and Fort Sask complex, further enhancing their operational efficiency.

My Personal Thoughts

These positive developments indicate Plains All American Pipeline’s commitment to growth and expansion. The acquisition in the Permian Basin strengthens their position in a prominent oil and gas region, while the expansion projects in the NGL segment demonstrate their focus on seizing opportunities and maximizing operational potential.


With the impressive financial results and strategic acquisitions, I recommend considering buying Plains All American Pipeline, L.P. stock. The company’s strong financial performance and expansion plans position them well for future success. It is worth monitoring their progress and evaluating potential entry points for investment.

Disclaimer: This is not financial advice. Please do your own research before making any investment decisions.

KALA BIO, Inc.: Making Strides in Ophthalmic Innovations

KALA BIO, Inc. (Nasdaq:KALA), a clinical-stage biopharmaceutical company specializing in rare and severe eye diseases, is making significant progress in their mission to develop groundbreaking therapies. The company recently unveiled their rebranded name, KALA BIO, Inc., reflecting their dedication to advancing biologics for the treatment of ophthalmic conditions.

One of their notable achievements is the $15 million grant awarded to their subsidiary, Combangio, Inc., by the California Institute for Regenerative Medicine (CIRM). This grant will support the ongoing KPI-012 program for the treatment of Posterior Corneal Epithelial Dystrophy (PCED), a rare and serious eye disease. Moreover, KALA BIO, Inc. is actively enrolling patients in the CHASE Phase 2b clinical trial for KPI-012, with topline data expected to be available by the second quarter of 2024.

As an investor, I am encouraged by the company’s progress and the investment received for their innovative programs. KALA BIO, Inc.’s strategic focus on rare ophthalmic diseases positions them well for future success. With a solid financial standing of $59.2 million in cash, cash equivalents, and short-term investments, alongside the CIRM grant, I believe the company is well-positioned to fund operations through the second quarter of 2025.

Given the positive developments and promising outlook, I recommend buying KALA BIO, Inc. stock. Their commitment to advancing novel biologics for the treatment of severe eye conditions makes them an attractive investment in the biopharmaceutical industry.

Achilles Therapeutics plc (ACHL): Promising Clinical Data and Strong Cash Position Support Future Growth

Achilles Therapeutics plc (NASDAQ: ACHL) recently announced their financial results for the second quarter of 2023, along with some exciting business highlights. The clinical-stage biopharmaceutical company is using AI-powered precision T cell therapies to target clonal neoantigens and treat solid tumors.

In the upcoming fourth quarter of 2023, Achilles Therapeutics expects to release clinical and translational science data from their ongoing Phase I/IIa trials in non-small cell lung cancer (NSCLC) and melanoma. This data will further validate the efficacy of their clonal neoantigen-reactive T cell (cNeT) therapy, which shows potential for treating advanced NSCLC and metastatic malignant melanoma.

The company’s bioinformatics platform, PELEUS™, is another asset in their arsenal. Their newly developed neoRanker™ tool, trained on a dataset of over 10,000 neoantigens, has shown the potential to identify multiple memory T cell responses more effectively than existing deep-learning models. This significant advancement in the field of neoantigen identification could bolster the design of neoantigen vaccines.

Financially, Achilles Therapeutics is in a robust position, with a cash balance of $144 million, enough to support their operations through 2025. This strong cash position instills confidence in their ability to continue developing innovative therapies and driving future growth.

As an investor, these developments are encouraging. With the upcoming data release and the potential of their AI-powered bioinformatics platform, Achilles Therapeutics demonstrates promise in the biopharmaceutical industry. Therefore, I recommend considering buying ACHL stock, as the positive news and strong cash position indicate future growth potential.

Note: This analysis is based on the information provided in the press release, and it is crucial to conduct further research and consult with a financial advisor before making any investment decisions.

AC Immune Reports Strong Q2 Financial Results and Receives FDA Fast Track Designation for Alzheimer’s Disease Treatment

AC Immune SA, a clinical-stage biopharmaceutical company specializing in precision medicine for neurodegenerative diseases, announced its second-quarter 2023 financial results and provided a corporate update. The highlight of the update is the recent FDA Fast Track Designation received for their ACI-24.060 anti-amyloid-beta (Abeta) active immunotherapy, intended to treat Alzheimer’s disease (AD).

Enrollment in the ongoing Phase 1b/2 ABATE study of ACI-24.060 has been progressing as planned. The study is examining the therapy’s effectiveness in both AD and Down syndrome (DS) patients. Following IND clearance, the study has expanded to include sites in the USA and has dosed the first individual with DS. The company expects to release interim safety and immunogenicity data from both the AD and DS cohorts in the second half of 2023.

Additionally, AC Immune anticipates results of amyloid plaque reduction analysis (Abeta-PET) in the ABATE study to be available in the first half of 2024. These results could potentially pave the way for the therapy’s transition into a registrational program. With a cash position of CHF 93.0 million, the company’s financials are secure until the third quarter of 2024, excluding anticipated milestone payments.

The Fast Track designation for ACI-24.060 acknowledges its potential as a next-generation anti-Abeta active immunotherapy. The therapy aims to offer improved efficacy, a safer profile, and fewer administration and distribution constraints compared to monoclonal antibodies. AC Immune’s CEO, Dr. Andrea Pfeifer, expressed confidence in the therapy’s progress, highlighting the momentum gained in the second half of 2023.

My personal thoughts on this update are positive. The FDA Fast Track Designation and the progress of the ABATE study signify significant milestones for AC Immune. The potential to transition into a registrational program based on efficacy demonstrated in the Abeta plaque reduction analysis is promising. With precision medicine being the focus for neurodegenerative diseases, AC Immune appears to be at the forefront of innovation.

Considering this positive update, I would recommend buying AC Immune stocks. The progress made in their clinical trials and the potential advancements in their pipeline make for a strong investment choice. AC Immune’s dedication to precision medicine gives them a competitive advantage in the field of neurodegenerative diseases.

Note: This article is not financial advice; it is based on personal opinions and the information provided in the press release. It is important to conduct thorough research and consult with a financial advisor before making any investment decisions.

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